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When collagen builds up under the skin, it may thicken and form a tight cord under the skin

the one or more hepatocyte growth factor mimics has or have a general structural formula R r R 2 -R 3 -NH-(CH 2 ) n -C-NH 2 Rj is one of an N-acyl group, a substituted or unsubstituted phenyl, a norleucine group, and an amino acid selected from tyrosine, phenylalanine, aspartic acid, arginine, isoleucine, serine, histidine, glycine, cysteine, methionine, tryptophan, lysine norvaline, ornithine, and s-benzyl cysteine

Povlsen B, Tegnell I

Subsequently, a full text review was performed, and the studies were classified according to their primary biomarker category, following the definitions of BEST (Biomarkers, EndpointS, and other Tools) Resource ( Discrepancies were resolved by consensus among the authors